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Human cytochrome CYP17A1. The structural basis for compromised lyase activity with 17-hydroxyprogesterone
The multifunctional enzyme, cytochrome P450 (CYP17A1), plays a crucial role in the production of androgens, catalyzing two key reactions on pregnenolone (PREG) and progesterone (PROG), the first being a 17-hydroxylation to generate 17-OH PREG and 17-OH PROG, with roughly equal efficiencies. The seco...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5999583/ https://ncbi.nlm.nih.gov/pubmed/29758981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b03901 |
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