Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression

The impact of mitochondrial dysfunction in epigenetics is emerging, but our understanding of this relationship and its effect on gene expression remains incomplete. We previously showed that acute mitochondrial DNA (mtDNA) loss leads to histone hypoacetylation. It remains to be defined if these chan...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Lozoya, Oswaldo A, Wang, Tianyuan, Grenet, Dagoberto, Wolfgang, Taylor C, Sobhany, Mack, Ganini da Silva, Douglas, Riadi, Gonzalo, Chandel, Navdeep, Woychik, Richard P, Santos, Janine H
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369536/
https://ncbi.nlm.nih.gov/pubmed/30737248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800228
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