Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation

Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (...

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Dettagli Bibliografici
Pubblicato in:PLoS Biol
Autori principali: Lozoya, Oswaldo A., Martinez-Reyes, Inmaculada, Wang, Tianyuan, Grenet, Dagoberto, Bushel, Pierre, Li, Jianying, Chandel, Navdeep, Woychik, Richard P., Santos, Janine H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
Soggetti:
Short Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927466/
https://ncbi.nlm.nih.gov/pubmed/29668680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005707
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