Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation

Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Lozoya, Oswaldo A., Martinez-Reyes, Inmaculada, Wang, Tianyuan, Grenet, Dagoberto, Bushel, Pierre, Li, Jianying, Chandel, Navdeep, Woychik, Richard P., Santos, Janine H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927466/
https://ncbi.nlm.nih.gov/pubmed/29668680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005707
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