Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

PURPOSE: While adoptive transfer of T cells bearing a chimeric antigen receptor (CAR) can eliminate substantial burdens of some leukemias, the ultimate challenge remains the eradication of large solid tumors for most cancers. We aimed to develop an immunotherapy approach effective against large tumo...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Slaney, Clare Y., von Scheidt, Bianca, Davenport, Alexander J., Beavis, Paul A., Westwood, Jennifer A., Mardiana, Sherly, Tscharke, David C., Ellis, Sarah, Prince, H. Miles, Trapani, Joseph A., Johnstone, Ricky W., Smyth, Mark J., Teng, Michele W., Ali, Aesha, Yu, Zhiya, Rosenberg, Steven A., Restifo, Nicholas P., Neeson, Paul, Darcy, Phillip K., Kershaw, Michael H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369535/
https://ncbi.nlm.nih.gov/pubmed/27965307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1860
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