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Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity
Chimeric antigen receptor T (CAR-T) cells are effective serial killers with a faster off-rate from dying tumor cells than CAR-T cells binding target cells through their T cell receptor (TCR). Here we explored the functional consequences of CAR-mediated signaling using a dual-specific CAR-T cell, whe...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5834689/ https://ncbi.nlm.nih.gov/pubmed/29440406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716266115 |
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