Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

Chimeric antigen receptor T (CAR-T) cells are effective serial killers with a faster off-rate from dying tumor cells than CAR-T cells binding target cells through their T cell receptor (TCR). Here we explored the functional consequences of CAR-mediated signaling using a dual-specific CAR-T cell, whe...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Davenport, A. J., Cross, R. S., Watson, K. A., Liao, Y., Shi, W., Prince, H. M., Beavis, P. A., Trapani, J. A., Kershaw, M. H., Ritchie, D. S., Darcy, P. K., Neeson, P. J., Jenkins, M. R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834689/
https://ncbi.nlm.nih.gov/pubmed/29440406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716266115
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