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Two‐stage design for phase I–II cancer clinical trials using continuous dose combinations of cytotoxic agents
We present a two-stage phase I/II design of a combination of two drugs in cancer clinical trials. The goal is to estimate safe dose combination regions with a desired level of efficacy. In stage I, conditional escalation with overdose control is used to allocate dose combinations to successive cohor...
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| Publicat a: | J R Stat Soc Ser C Appl Stat |
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| Autor principal: | |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6368405/ https://ncbi.nlm.nih.gov/pubmed/30745708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/rssc.12294 |
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