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Dose Finding for Drug Combination in Early Cancer Phase I Trials using Conditional Continual Reassessment Method
We describe a dose escalation algorithm for drug combinations in cancer phase I clinical trials. Parametric models for describing the association between the doses and the probability of dose limiting toxicity are used assuming univariate monotonicity of the dose-toxicity relationship. Trial design...
Enregistré dans:
| Publié dans: | J Biom Biostat |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5851015/ https://ncbi.nlm.nih.gov/pubmed/29552377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2155-6180.1000381 |
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