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A Bayesian seamless phase I-II trial design with two stages for cancer clinical trials with drug combinations
The use of drug combinations in clinical trials is increasingly common during the last years since a more favorable therapeutic response may be obtained by combining drugs. In phase I clinical trials, most of the existing methodology recommends a one unique dose combination as “optimal,” which may r...
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| Veröffentlicht in: | Biom J |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7483235/ https://ncbi.nlm.nih.gov/pubmed/32150296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201900095 |
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