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A Bayesian seamless phase I-II trial design with two stages for cancer clinical trials with drug combinations

The use of drug combinations in clinical trials is increasingly common during the last years since a more favorable therapeutic response may be obtained by combining drugs. In phase I clinical trials, most of the existing methodology recommends a one unique dose combination as “optimal,” which may r...

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Bibliographische Detailangaben
Veröffentlicht in:Biom J
Hauptverfasser: Jiménez, José L., Kim, Sungjin, Tighiouart, Mourad
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483235/
https://ncbi.nlm.nih.gov/pubmed/32150296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201900095
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