Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort

AIM: Previous studies suggest telomere shortening represses PGC1A and PGC1B expression leading to mitochondrial dysfunction. Methylation of CpG sites within these genes may interact with these factors to affect cancer risk. MATERIALS & METHODS: Among 385 men, we identified 84 incidents of cancer...

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Detalhes bibliográficos
Publicado no:Epigenomics
Main Authors: Kresovich, Jacob K, Joyce, Brian T, Gao, Tao, Zheng, Yinan, Zhang, Zhou, Achenbach, Christopher J, Murphy, Robert L, Just, Allan C, Shen, Jincheng, Yang, Hushan, Vokonas, Pantel, Schwartz, Joel, Baccarelli, Andrea A, Hou, Lifang
Formato: Artigo
Idioma:Inglês
Publicado em: Future Medicine Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367713/
https://ncbi.nlm.nih.gov/pubmed/29888964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/epi-2017-0141
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