APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications

We here investigate how APRIL impacts immune regulatory T cells and directly contributes to the immunosuppressive multiple myeloma (MM) bone marrow (BM) microenvironment. First, APRIL receptor TACI expression is significantly higher in regulatory T cells (Tregs) than conventional T cells (Tcons) fro...

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Bibliografiske detaljer
Udgivet i:Leukemia
Main Authors: Tai, Yu-Tzu, Lin, Liang, Xing, Lijie, Cho, Shih-Feng, Yu, Tengteng, Acharya, Chirag, Wen, Kenneth, Hsieh, Phillip A, Dulos, John, van Elsas, Andrea, Munshi, Nikhil, Richardson, Paul, Anderson, Kenneth C
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367000/
https://ncbi.nlm.nih.gov/pubmed/30135465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0242-6
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