Preclinical evaluation of CD8+ anti-BCMA mRNA CAR T-cells for treatment of multiple myeloma

Chimeric antigen receptor (CAR) T-cell therapy remains limited to select centers that can carefully monitor adverse events. To broaden use of CAR T-cells in community clinics and in a frontline setting, we developed a novel CD8+ CAR T-cell product, Descartes-08, with predictable pharmacokinetics for...

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Veröffentlicht in:Leukemia
Hauptverfasser: Lin, Liang, Cho, Shih-Feng, Xing, Lijie, Wen, Kenneth, Li, Yuyin, Yu, Tengteng, Hsieh, Phillip A., Chen, Hailin, Kurtoglu, Metin, Zhang, Yi, Stewart, C Andrew, Munshi, Nikhil, Anderson, Kenneth C, Tai, Yu-Tzu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785573/
https://ncbi.nlm.nih.gov/pubmed/32632095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0951-5
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