Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCP

Merkel cell polyomavirus (MCPyV) accounts for 80% of all Merkel cell carcinoma (MCC) cases through expression of two viral oncoproteins: the truncated large T antigen (LT-t) and small T antigen (ST). MCPyV ST is thought to be the main driver of cellular transformation and has also been shown to incr...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Dye, Kristine N., Welcker, Markus, Clurman, Bruce E., Roman, Ann, Galloway, Denise A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366716/
https://ncbi.nlm.nih.gov/pubmed/30689667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007543
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