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Double-strand break repair plays a role in repeat instability in a Fragile X mouse model.

Expansion of a CGG-repeat tract in the 5’UTR of FMR1 is responsible for the Fragile X-related disorders (FXDs), FXTAS, FXPOI and FXS. Previous work in a mouse model of these disorders has implicated proteins in the base excision and the mismatch repair pathways in the expansion mechanism. However, t...

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Bibliografiske detaljer
Udgivet i:DNA Repair (Amst)
Main Authors: Gazy, Inbal, Hayward, Bruce, Potapova, Svetlana, Zhao, Xiaonan, Usdin, Karen
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366319/
https://ncbi.nlm.nih.gov/pubmed/30606610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.12.004
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