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Double-strand break repair plays a role in repeat instability in a Fragile X mouse model.
Expansion of a CGG-repeat tract in the 5’UTR of FMR1 is responsible for the Fragile X-related disorders (FXDs), FXTAS, FXPOI and FXS. Previous work in a mouse model of these disorders has implicated proteins in the base excision and the mismatch repair pathways in the expansion mechanism. However, t...
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| Publicado no: | DNA Repair (Amst) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6366319/ https://ncbi.nlm.nih.gov/pubmed/30606610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.12.004 |
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