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Inhibition of the PI3K/AKT/mTOR Pathway in Solid Tumors

The phosphoinositide 3-kinase (PI3K) pathway plays an integral role in many cellular processes and is frequently altered in cancer, contributing to tumor growth and survival. Small molecule inhibitors have been developed that target the three major nodes of this pathway: PI3K, AKT, and mammalian tar...

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Pubblicato in:J Clin Oncol
Autore principale: LoRusso, Patricia Mucci
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366304/
https://ncbi.nlm.nih.gov/pubmed/27621407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.59.0018
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