Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism

Cholesterolysis of Hedgehog family proteins couples endoproteolysis to protein C-terminal sterylation. The transformation is self-catalyzed by HhC, a partially characterized enzymatic domain found in precursor forms of Hedgehog. Here we explore spatial ambiguity in sterol recognition by HhC, using a...

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Bibliographic Details
Published in:Chem Commun (Camb)
Main Authors: Ciulla, Daniel A., Wagner, Andrew G., Xinyue, Liu, Cooper, Courtney L., Jorgensen, Michael T., Wang, Chunyu, Goyal, Puja, Banavali, Nilesh K., Pezzullo, John, Giner, José-Luis, Callahan, Brian P.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365966/
https://ncbi.nlm.nih.gov/pubmed/30672911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc09729a
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