ICOS-deficient regulatory T cells display normal induction of Il10 but readily downregulate expression of Foxp3

The ICOS pathway has been implicated in the development and functions of regulatory T cells (Treg cells) including those producing IL-10. Treg cell-derived IL-10 is indispensable for the establishment and maintenance of intestinal immune homeostasis. We examined the possible involvement of the ICOS...

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Vydáno v:J Immunol
Hlavní autoři: Landuyt, Ashley E., Klocke, Barbara J., Colvin, Tyler B., Schoeb, Trenton R., Maynard, Craig L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363853/
https://ncbi.nlm.nih.gov/pubmed/30642977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801266
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