TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

Comprehensively elucidating the molecular mechanisms of human immunodeficiency virus type 1 (HIV-1) latency is a priority to achieve a functional cure. As current 'shock' agents failed to efficiently reactivate the latent reservoir, it is important to discover new targets for developing mo...

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Veröffentlicht in:eLife
Hauptverfasser: Ma, Xiancai, Yang, Tao, Luo, Yuewen, Wu, Liyang, Jiang, Yawen, Song, Zheng, Pan, Ting, Liu, Bingfeng, Liu, Guangyan, Liu, Jun, Yu, Fei, He, Zhangping, Zhang, Wanying, Yang, Jinyu, Liang, Liting, Guan, Yuanjun, Zhang, Xu, Li, Linghua, Cai, Weiping, Tang, Xiaoping, Gao, Song, Deng, Kai, Zhang, Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Microbiology and Infectious Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361614/
https://ncbi.nlm.nih.gov/pubmed/30652970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42426
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