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Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity
5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the pop...
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| 出版年: | Autops Case Rep |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
São Paulo, SP: Universidade de São Paulo, Hospital Universitário
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6360833/ https://ncbi.nlm.nih.gov/pubmed/30775324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4322/acr.2018.049 |
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