Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity

5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the pop...

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Detalhes bibliográficos
Publicado no:Autopsy and Case Reports
Main Authors: Shiraz S. Fidai, Aarti E. Sharma, Daniel N. Johnson, Jeremy P. Segal, Ricardo R. Lastra
Formato: Artigo
Idioma:Inglês
Publicado em: Hospital Universitário da Universidade de São Paulo 2018
Assuntos:
Medicina
Drug
Fluorouracil
Pancytopenia
Genetic Testing
Dihydropyrimidine Dehydrogenase Deficiency
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