Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity
5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the pop...
Gardado en:
| Publicado en: | Autopsy and Case Reports |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Hospital Universitário da Universidade de São Paulo
2018
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| Assuntos: | |
| Acceso en liña: | https://www.redalyc.org/articulo.oa?id=576068199009 https://www.redalyc.org/journal/5760/576068199009/ https://www.redalyc.org/journal/5760/576068199009/html/ https://www.redalyc.org/journal/5760/576068199009/576068199009.epub https://www.redalyc.org/journal/5760/576068199009/movil |
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