Unpredicted Severe Toxicity after 5-Fluorouracil Treatment due to Dihydropyrimidine Dehydrogenase Deficiency

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). Thus, patients with a DPD deficiency are at risk of developing severe 5-FU-associated toxicity. A 37-year-old female with gastric cancer underwent a curative operation, followed...

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Bibliographic Details
Main Authors: Baek, Jin Ho, Kim, Jong Gwang, Kim, Shi Nae, Kim, Dong Hwan, Sohn, Sang Kyun, Hong, Young Jun, Lee, Kyu Bo
Format: Artigo
Language:Inglês
Published: The Korean Association of Internal Medicine 2006
Subjects:
Case Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891063/
https://ncbi.nlm.nih.gov/pubmed/16646564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3904/kjim.2006.21.1.43
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