Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors

BACKGROUND: Nasopharyngeal carcinoma (NPC), a highly invasive tumor, exhibits a distinctive racial and geographic distribution. As options of agents for effective combination chemoradiotherapy for advanced NPC are limited, novel therapeutic approaches are desperately needed. Here the potential of si...

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Bibliographic Details
Published in:	J Biomed Sci
Main Authors:	Wang, Zhihai, Zuo, Wenqi, Zeng, Quan, Qian, Yi, Li, Yanshi, Liu, Chuan, Wang, Jue, Zhong, Shixun, Bu, Youquan, Hu, Guohua
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2019
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6360700/ https://ncbi.nlm.nih.gov/pubmed/30717758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-019-0507-z
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Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors

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