Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib

Leiomyosarcoma (LMS) is characterized by high genomic complexity, and to date, no specific targeted therapy is available. In a genome-wide approach, we profiled genomic aberrations in a small cohort of eight primary tumours, two relapses, and eight metastases across nine different patients. We ident...

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Detalhes bibliográficos
Publicado no:Sarcoma
Main Authors: Böhm, Michael J., Marienfeld, Ralf, Jäger, Daniela, Mellert, Kevin, von Witzleben, Adrian, Brüderlein, Silke, Wittau, Mathias, von Baer, Alexandra, Schultheiss, Markus, Mayer-Steinacker, Regine, Rücker, Frank G., Möller, Peter, Bullinger, Lars, Barth, Thomas F. E.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360577/
https://ncbi.nlm.nih.gov/pubmed/30804704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3914232
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