Profiling of three H3F3A-mutated and denosumab-treated giant cell tumors of bone points to diverging pathways during progression and malignant transformation

Giant cell tumor of bone (GCTB) is a locally aggressive lesion of intermediate malignancy. Malignant transformation of GCTB is a rare event. In 2013, the humanized monoclonal antibody against receptor activator of nuclear factor-κb-Ligand (RANKL) denosumab was approved for treatment of advanced GCTB...

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Publicado en:Sci Rep
Autores principales: Hasenfratz, Marc, Mellert, Kevin, Marienfeld, Ralf, von Baer, Alexandra, Schultheiss, Markus, Roitman, P. D., Aponte-Tinao, L. A., Lehner, Burkhard, Möller, Peter, Mechtersheimer, Gunhild, Barth, Thomas F. E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7952552/
https://ncbi.nlm.nih.gov/pubmed/33707617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85319-x
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