Characterization of Three Novel H3F3A-mutated Giant Cell Tumor Cell Lines and Targeting of Their Wee1 Pathway

The giant cell tumor of bone (GCTB) is a locally aggressive primary bone tumor that is composed of mononuclear stroma cells, scattered macrophages, and multinucleated osteoclast-like giant cells which cause pathologic osteolysis. The stroma cells represent the neoplastic population of the tumor and...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Lübbehüsen, Christoph, Lüke, Julian, Seeling, Carolin, Mellert, Kevin, Marienfeld, Ralf, von Baer, Alexandra, Schultheiss, Markus, Möller, Peter, Barth, Thomas F. E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478864/
https://ncbi.nlm.nih.gov/pubmed/31015476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42611-1
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