Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1–Mediated Cholesterol Removal

CYP46A1 is the cytochrome P450 enzyme that converts cholesterol to 24-hydroxycholesterol, a cholesterol elimination product and a potent liver X receptor (LXR) ligand. We conducted retinal characterizations of Cyp46a1(−/−) mice that had normal fasting blood glucose levels but up to a 1.8-fold increa...

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Udgivet i:Am J Pathol
Main Authors: Saadane, Aicha, Mast, Natalia, Trichonas, George, Chakraborty, Dibyendu, Hammer, Sandra, Busik, Julia V., Grant, Maria B., Pikuleva, Irina A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360352/
https://ncbi.nlm.nih.gov/pubmed/30448403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.10.013
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