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Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1–Mediated Cholesterol Removal
CYP46A1 is the cytochrome P450 enzyme that converts cholesterol to 24-hydroxycholesterol, a cholesterol elimination product and a potent liver X receptor (LXR) ligand. We conducted retinal characterizations of Cyp46a1(−/−) mice that had normal fasting blood glucose levels but up to a 1.8-fold increa...
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| Publicado en: | Am J Pathol |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Investigative Pathology
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6360352/ https://ncbi.nlm.nih.gov/pubmed/30448403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.10.013 |
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