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Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1–Mediated Cholesterol Removal
CYP46A1 is the cytochrome P450 enzyme that converts cholesterol to 24-hydroxycholesterol, a cholesterol elimination product and a potent liver X receptor (LXR) ligand. We conducted retinal characterizations of Cyp46a1(−/−) mice that had normal fasting blood glucose levels but up to a 1.8-fold increa...
Zapisane w:
| Wydane w: | Am J Pathol |
|---|---|
| Główni autorzy: | , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Investigative Pathology
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6360352/ https://ncbi.nlm.nih.gov/pubmed/30448403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.10.013 |
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