Cholesterol-Metabolizing Enzyme Cytochrome P450 46A1 as a Pharmacologic Target for Alzheimer’s Disease

Cytochrome P450 46A1 (CYP46A1 or cholesterol 24-hydroxylase) controls cholesterol elimination from the brain and plays a role in higher order brain functions. Genetically enhanced CYP46A1 expression in mouse models of Alzheimer’s disease mitigates the manifestations of this disease. We enhanced CYP4...

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Pubblicato in:Neuropharmacology
Autori principali: Mast, Natalia, Saadane, Aicha, Valencia-Olvera, Ana, Constans, James, Maxfield, Erin, Arakawa, Hiroyuki, Li, Young, Landreth, Gary, Pikuleva, Irina A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546235/
https://ncbi.nlm.nih.gov/pubmed/28655608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.06.026
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