Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets

BACKGROUND & AIMS: Diminished forkhead box O3 (FOXO3) function drives inflammation and cancer growth; however, mechanisms fostering these pathobiologies are unclear. Here, we aimed to identify in colon loss of FOXO3-dependent cellular and molecular changes that facilitate inflammation-mediated t...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Penrose, Harrison M., Cable, Chloe, Heller, Sandra, Ungerleider, Nathan, Nakhoul, Hani, Baddoo, Melody, Hartono, Alifiani B., Lee, Sean B., Burow, Matthew E., Flemington, Erik F., Crawford, Susan E., Savkovic, Suzana D.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360252/
https://ncbi.nlm.nih.gov/pubmed/30718226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.10.003
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