Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets

BACKGROUND & AIMS: Diminished forkhead box O3 (FOXO3) function drives inflammation and cancer growth; however, mechanisms fostering these pathobiologies are unclear. Here, we aimed to identify in colon loss of FOXO3-dependent cellular and molecular changes that facilitate inflammation-mediated t...

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Détails bibliographiques
Publié dans:Cell Mol Gastroenterol Hepatol
Auteurs principaux: Penrose, Harrison M., Cable, Chloe, Heller, Sandra, Ungerleider, Nathan, Nakhoul, Hani, Baddoo, Melody, Hartono, Alifiani B., Lee, Sean B., Burow, Matthew E., Flemington, Erik F., Crawford, Susan E., Savkovic, Suzana D.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2018
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360252/
https://ncbi.nlm.nih.gov/pubmed/30718226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.10.003
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