Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation

Intestinal inflammation is associated with low levels of mucosal ATP, highlighting the importance of mitochondrial function associated with ATP production in the pathophysiology of the disease. In the inflamed colon of humans and mice, we found decreased levels of mitochondrial complex cytochrome c...

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Bibliographic Details
Published in:FASEB J
Main Authors: Heller, Sandra, Penrose, Harrison M., Cable, Chloe, Biswas, Debjani, Nakhoul, Hani, Baddoo, Melody, Flemington, Erik, Crawford, Susan E., Savkovic, Suzana D.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388551/
https://ncbi.nlm.nih.gov/pubmed/28183804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600976R
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