Arid1a is essential for intestinal stem cells through Sox9 regulation

Inactivating mutations of Arid1a, a subunit of the Switch/sucrose nonfermentable chromatin remodeling complex, have been reported in multiple human cancers. Intestinal deletion of Arid1a has been reported to induce colorectal cancer in mice; however, its functional role in intestinal homeostasis rem...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Hiramatsu, Yukiko, Fukuda, Akihisa, Ogawa, Satoshi, Goto, Norihiro, Ikuta, Kozo, Tsuda, Motoyuki, Matsumoto, Yoshihide, Kimura, Yoshito, Yoshioka, Takuto, Takada, Yutaka, Maruno, Takahisa, Hanyu, Yuta, Tsuruyama, Tatsuaki, Wang, Zhong, Akiyama, Haruhiko, Takaishi, Shigeo, Miyoshi, Hiroyuki, Taketo, Makoto Mark, Chiba, Tsutomu, Seno, Hiroshi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2019
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358682/
https://ncbi.nlm.nih.gov/pubmed/30635419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804858116
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