Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

TAK-875 (fasiglifam), a GPR40 agonist in development for the treatment of type 2 diabetes (T2D), was voluntarily terminated in Phase III trials due to adverse liver effects. The potential mechanisms of TAK-875 toxicity were explored by combining in vitro experiments with quantitative systems toxicol...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Longo, Diane M, Woodhead, Jeffrey L, Walker, Paul, Herédi-Szabó, Krisztina, Mogyorósi, Károly, Wolenski, Francis S, Dragan, Yvonne P, Mosedale, Merrie, Siler, Scott Q, Watkins, Paul B, Howell, Brett A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Tak-875 Liver Injury: Bile Acid and Mitochondrial Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358270/
https://ncbi.nlm.nih.gov/pubmed/30289550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy253
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