Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

[Image: see text] GPR40, one of the G protein-coupled receptors predominantly expressed in pancreatic β-cells, mediates enhancement of glucose-stimulated insulin secretion by free fatty acids. A potent and selective GPR40 agonist is theorized to be a safe and effective antidiabetic drug with little...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Negoro, Nobuyuki, Sasaki, Shinobu, Mikami, Satoshi, Ito, Masahiro, Suzuki, Masami, Tsujihata, Yoshiyuki, Ito, Ryo, Harada, Ayako, Takeuchi, Koji, Suzuki, Nobuhiro, Miyazaki, Junichi, Santou, Takashi, Odani, Tomoyuki, Kanzaki, Naoyuki, Funami, Miyuki, Tanaka, Toshimasa, Kogame, Akifumi, Matsunaga, Shinichiro, Yasuma, Tsuneo, Momose, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007909/
https://ncbi.nlm.nih.gov/pubmed/24900210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1000855
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados