Fasiglifam (TAK-875), a G Protein-Coupled Receptor 40 (GPR40) Agonist, May Induce Hepatotoxicity through Reactive Oxygen Species Generation in a GPR40-Dependent Manner

Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical trials, unexpected liver toxicity resulted in pr...

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Detalhes bibliográficos
Publicado no:Biomol Ther (Seoul)
Main Authors: Kim, MinJeong, Gu, Gyo Jeong, Koh, Yun-Sook, Lee, Su-Hyun, Na, Yi Rang, Seok, Seung Hyeok, Lim, Kyung-Min
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society of Applied Pharmacology 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254646/
https://ncbi.nlm.nih.gov/pubmed/29429148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2017.225
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