Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects With Type 2 Diabetes Mellitus

The G-protein-coupled receptor 40 agonist (GPR40) TAK-875 is being developed as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. Pharmacometric approaches such as model-based exposure-response and meta-analyses were applied to (i) characterize ex...

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Bibliografiske detaljer
Main Authors: Naik, H, Lu, J, Cao, C, Pfister, M, Vakilynejad, M, Leifke, E
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600727/
https://ncbi.nlm.nih.gov/pubmed/23887592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.23
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