טוען...
Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design
Two major pharmacological hurdles severely limit the widespread use of small peptides as therapeutics: poor proteolytic stability and membrane permeability. Importantly, low aqueous solubility also impedes the development of peptides for clinical use. Various elaborate side chain stapling chemistrie...
שמור ב:
| הוצא לאור ב: | Chem Sci |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Royal Society of Chemistry
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6357863/ https://ncbi.nlm.nih.gov/pubmed/30809370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc03275k |
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