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Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High‐Fat Diet
Phosphatidylethanolamine N‐methyltransferase (PEMT) is a hepatic integral membrane protein localized to the endoplasmic reticulum (ER). PEMT catalyzes approximately 30% of hepatic phosphatidylcholine (PC) biosynthesis. Pemt(–/–) mice fed a high‐fat diet (HFD) develop steatohepatitis. Interestingly,...
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| Publicat a: | Hepatol Commun |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6357837/ https://ncbi.nlm.nih.gov/pubmed/30766963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1302 |
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