Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase

Mice lacking phosphatidylethanolamine N-methyltransferase (PEMT) are protected from high-fat diet (HFD)-induced obesity and insulin resistance. However, these mice develop severe nonalcoholic fatty liver disease (NAFLD) when fed the HFD, which is mainly due to inadequate secretion of VLDL particles....

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Publicado en:J Lipid Res
Autores principales: van der Veen, Jelske N., Lingrell, Susanne, Gao, Xia, Takawale, Abhijit, Kassiri, Zamaneh, Vance, Dennis E., Jacobs, René L.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2017
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392742/
https://ncbi.nlm.nih.gov/pubmed/28159867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M070631
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