Choline Supplementation Promotes Hepatic Insulin Resistance in Phosphatidylethanolamine N-Methyltransferase-deficient Mice via Increased Glucagon Action

Biosynthesis of hepatic choline via phosphatidylethanolamine N-methyltransferase (PEMT) plays an important role in the development of type 2 diabetes and obesity. We investigated the mechanism(s) by which choline modulates insulin sensitivity. PEMT wild-type (Pemt(+/+)) and knock-out (Pemt(−/−)) mic...

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Detalhes bibliográficos
Main Authors: Wu, Gengshu, Zhang, Liyan, Li, Tete, Zuniga, Azeret, Lopaschuk, Gary D., Li, Liang, Jacobs, René L., Vance, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543033/
https://ncbi.nlm.nih.gov/pubmed/23179947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415117
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