Impaired de Novo Choline Synthesis Explains Why Phosphatidylethanolamine N-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current study investigates whether or not hepatic PC...

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Detalhes bibliográficos
Main Authors: Jacobs, René L., Zhao, Yang, Koonen, Debby P. Y., Sletten, Torunn, Su, Brian, Lingrell, Susanne, Cao, Guoqing, Peake, David A., Kuo, Ming-Shang, Proctor, Spencer D., Kennedy, Brian P., Dyck, Jason R. B., Vance, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903412/
https://ncbi.nlm.nih.gov/pubmed/20452975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.108514
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