Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis

De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-α (CTα) is required for VLDL secretion. To determine the precise role of de novo PC synthesis in intestinal lipid metabolism, we deleted CTα exclusively in the intestinal epithelium of mice (CTα(IKO) mice). When f...

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Bibliografische gegevens
Gepubliceerd in:J Lipid Res
Hoofdauteurs: Kennelly, John P., van der Veen, Jelske N., Nelson, Randal C., Leonard, Kelly-Ann, Havinga, Rick, Buteau, Jean, Kuipers, Folkert, Jacobs, René L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2018
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121921/
https://ncbi.nlm.nih.gov/pubmed/30007917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M087056
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