Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High‐Fat Diet

Phosphatidylethanolamine N‐methyltransferase (PEMT) is a hepatic integral membrane protein localized to the endoplasmic reticulum (ER). PEMT catalyzes approximately 30% of hepatic phosphatidylcholine (PC) biosynthesis. Pemt(–/–) mice fed a high‐fat diet (HFD) develop steatohepatitis. Interestingly,...

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Detalhes bibliográficos
Publicado no:Hepatol Commun
Main Authors: Wan, Sereana, Kuipers, Folkert, Havinga, Rick, Ando, Hiromi, Vance, Dennis E., Jacobs, René L., van der Veen, Jelske N.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6357837/
https://ncbi.nlm.nih.gov/pubmed/30766963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1302
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