Oxidation of Peroxiredoxin 6 in the Presence of GSH Increases its Phospholipase A(2) Activity at Cytoplasmic pH

The expression of the phospholipase A(2) activity (aiPLA(2)) of peroxiredoxin 6 (Prdx6) in the cell cytoplasm is physiologically relevant for the repair of peroxidized cell membranes, but aiPLA(2) assay in vitro indicates that, unlike assay at pH 4, activity at cytosolic pH is essentially absent wit...

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Gepubliceerd in:Antioxidants (Basel)
Hoofdauteurs: Zhou, Suiping, Dodia, Chandra, Feinstein, Sheldon I., Harper, Sandra, Forman, Henry J., Speicher, David W., Fisher, Aron B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6357108/
https://ncbi.nlm.nih.gov/pubmed/30586895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox8010004
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