Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation

Erythropoiesis is the complex, dynamic, and tightly regulated process that generates all mature red blood cells. To understand this process, we mapped the developmental trajectories of progenitors from wild-type, erythropoietin-treated, and Flvcr1-deleted mice at single-cell resolution. Importantly,...

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Veröffentlicht in:Blood
Hauptverfasser: Doty, Raymond T., Yan, Xiaowei, Lausted, Christopher, Munday, Adam D., Yang, Zhantao, Yi, Danielle, Jabbari, Neda, Liu, Li, Keel, Siobán B., Tian, Qiang, Abkowitz, Janis L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Red Cells, Iron, and Erythropoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356983/
https://ncbi.nlm.nih.gov/pubmed/30530752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-05-850412
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