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Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation

Erythropoiesis is the complex, dynamic, and tightly regulated process that generates all mature red blood cells. To understand this process, we mapped the developmental trajectories of progenitors from wild-type, erythropoietin-treated, and Flvcr1-deleted mice at single-cell resolution. Importantly,...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Doty, Raymond T., Yan, Xiaowei, Lausted, Christopher, Munday, Adam D., Yang, Zhantao, Yi, Danielle, Jabbari, Neda, Liu, Li, Keel, Siobán B., Tian, Qiang, Abkowitz, Janis L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356983/
https://ncbi.nlm.nih.gov/pubmed/30530752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-05-850412
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