Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation

Erythropoiesis is the complex, dynamic, and tightly regulated process that generates all mature red blood cells. To understand this process, we mapped the developmental trajectories of progenitors from wild-type, erythropoietin-treated, and Flvcr1-deleted mice at single-cell resolution. Importantly,...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Doty, Raymond T., Yan, Xiaowei, Lausted, Christopher, Munday, Adam D., Yang, Zhantao, Yi, Danielle, Jabbari, Neda, Liu, Li, Keel, Siobán B., Tian, Qiang, Abkowitz, Janis L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356983/
https://ncbi.nlm.nih.gov/pubmed/30530752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-05-850412
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