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Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products

A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure–activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity agains...

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Bibliografski detalji
Izdano u:Mar Drugs
Glavni autori: Matsubara, Takehiro, Yokoya, Masashi, Sirimangkalakitti, Natchanun, Saito, Naoki
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356950/
https://ncbi.nlm.nih.gov/pubmed/30577460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md17010003
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