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Synthesis and Evaluation of a Chitosan Oligosaccharide-Streptomycin Conjugate against Pseudomonas aeruginosa Biofilms

Microbial biofilms are considerably more resistant to antibiotics than planktonic cells. It has been reported that chitosan coupling with the aminoglycoside antibiotic streptomycin dramatically disrupted biofilms of several Gram-positive bacteria. This finding suggested the application of the covale...

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Bibliographic Details
Published in:Mar Drugs
Main Authors: Li, Ruilian, Yuan, Xianghua, Wei, Jinhua, Zhang, Xiafei, Cheng, Gong, Wang, Zhuo A., Du, Yuguang
Format: Artigo
Language:Inglês
Published: MDPI 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356912/
https://ncbi.nlm.nih.gov/pubmed/30634609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md17010043
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