Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV

Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus with a crude mortality rate of ~35%. Previously, we established a human DPP4 transgenic (hDPP4-Tg) mouse model in which we studied complement overactivation-induced immunopathogenesis. Here, to better understand the...

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Опубликовано в: :Viruses
Главные авторы: Jiang, Yuting, Li, Junfeng, Teng, Yue, Sun, Hong, Tian, Guang, He, Lei, Li, Pei, Chen, Yuehong, Guo, Yan, Li, Jiangfan, Zhao, Guangyu, Zhou, Yusen, Sun, Shihui
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356766/
https://ncbi.nlm.nih.gov/pubmed/30634407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v11010039
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